Effect of E6060 (4-{5-[7-fluoro-4-(trifluoromethyl)benzo[b]furan-2-yl]-1H-2-pyrrolyl}benzoic acid), a novel subtype-selective retinoid, on lupus-like nephritis in female (NZBxNZW)F1
نویسندگان
چکیده
Tsukuba Research Laboratories, Eisai Co., Ltd., Tokodai 5-1-3, Tsukuba Science City, Ibaraki, 300-2635, Japan (T.Y., A.I., K.S., N.T., M.N.); RIKEN Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi, Yokohama, Kanagawa 230-0045, Japan (K.S.); PRESTO, JST, Kawaguchi, Saitama 332-0012, Japan (K.S.); and Eisai Research Institute, Eisai Co., Ltd., 100 Research Drive, Wilmington, MA, 01887, U.S.A. (S.K.) JPET Fast Forward. Published on December 22, 2004 as DOI:10.1124/jpet.104.075598
منابع مشابه
Effect of E6060 [4-{5-[7-fluoro-4-(trifluoromethyl)benzo[b]furan-2-yl]-1H-2-pyrrolyl}benzoic acid], a novel subtype-selective retinoid, on lupus-like nephritis in female (NZBxNZW)F1 mice.
Disease amelioration by retinoids in various nephritic models has been reported from either immunological or pathophysiologic viewpoints. It has also been reported that retinoids exert immunosuppressive effects in a retinoic acid receptor (RAR)-alpha-dependent manner. In particular, synthetic retinoid agonists with selectivity to RAR-alpha have been reported to have a remarkable disease-amelior...
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تاریخ انتشار 2004